microcrystalline cellulose msds fmc microcrystalline cellulose msds fmc

SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. These, in turn, are assembled into fibrils in the cell wall. >> : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. EMCOCEL 90 M. 130. Request media, explore upcoming events and read our latest updates. Product and Company Identification . Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. The figure below illustrates the structural organisation of cellulose within plants. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . (1962). CAS 9004-34-6, pH 5 - 7.5. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. All rights reserved. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. 2008-2023 ChemPoint. Learn about FMC's differentiated biologically-based crop solutions. stream Looking for FMC'searnings news? MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no A family of polysaccharide products that allow distinctive drug delivery solutions. SUBSTANCE IDENTIFICATION 1.1. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. ( Aqueous suspensions of microcrystalline cellulose have . pH 6.0 to 8.0 . pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. SDS. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. Created Date: 2/10/2020 8:51:41 PM . 1. ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! Avicel Microcrystalline Cellulose: Chemical Identifiers. Manufactured by: China . It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. [FMC Study Number I92-1464]. It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. *r_ *?~4$ &0Y# Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. lH5JWy}DgKRR"Fs Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . These grades have particle sizes ranging from <30 to approximately 200. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. Date Approved: 05/25/2010. Protect them from sunshine or rain. %PDF-1.4 It . endobj YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. Unique functionality for a broad range of pharmaceutical applications. It is available in different grades and particle sizes. stream Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. Powder becomes slippery when wet. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. Are you sure you want to delete your template? Micro Crystalline Cellulose. It is, however, a good source of fibre. It is also used in plaque assays for counting. endobj PharmaCentral 2021 . Fiber supplements can lessen the absorption of some . Microcrystalline Cellulose. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. No. No. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. MSDS Ref. CAS #: 9004-34-6 1.6. It is a white, free-flowing powder. 4 0 obj The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. Watch Now. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . endobj Alginates also function as actives in some anti-reflux products. 130. More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . ( Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. >> CoA. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. /Parent 3 0 R . Manufacturer: FMC BioPolymer. Quick Links. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . Battista, O. MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. : CL-611NF Date Approved: 01/13/2010. Go to Investor Relations. Microcrystalline Cellulose; Cellulose; Functions. For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Earth Supplied Products LLC. Microcrystalline Cellulose NF. Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . Trademarks: Avicel PH-102. Microcrystalline cellulose is a commonly used excipient in the . <> gwf;J(e0o|1p{R~P^);ao!%{0KD7. Product Name: Microcrystalline Cellulose 1.2. However, consumption of large quantities of the material may have a laxative effect. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. . endobj Home. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. Avicel PH-200 microcrystalline cellulose NF, Ph. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. 4 0 obj Avicel PC 611 Microcrystalline Cellulose. stream It is also inert and biocompatible. We know that our customers need to provide reliable and consistent products to their patients. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. 2021 Annual Report. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. Chemical Formula: (C6H10O5)n 1.4. ChemicalBook. If breathing is difficult or if . With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. Delivering efficient and robust formulations. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. Microcrystalline Cellulose / Avicel PH-102. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . They are made up of sulfated and non-sulfated repeating units of galactose and 3,6-anhydrogalactose. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. % if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. It is . An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. FMC Corporation. We are artists at heart and creators by nature. This Microcrystalline Cellulose . Product Name Cellulose microcrystalline. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. : 5. <> All Rights Reserved. Microcrystalline Cellulose (MCC) MSDS 1. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. 8 0 obj Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe Since cellulose contains both amorphous and crystalline regions, when the crystalline regions are mechanically and chemically isolated and elaborated, various useful ingredients in the form of cellulose crystals are obtained, one of which is Avicel Microcrystalline cellulose. In large quantities it provides dietary bulk and may lead to a laxative effect. JFIF ` ` ZExif MM * J Q Q Q C Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Performing this action will revert the following features to their default settings: Hooray! stream Have an order or account question, find answers in our Online Support articles. << Avicel RC-591 & CL-611 - Description. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. United Nations Sustainable Development Goals, Alginates Protanal, Manucol, Protacid and More, Barrier membrane, Controlled release hydrophilic matrix, Taste masking, Carrageenan Gelcarin, Viscarin and More, Controlled release hydrophilic matrix, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Rheology modifier, Rheology modifier/stabilizer, Binder, Controlled release hydrophilic matrix, Rheology modifier, Rheology modifier/stabilizer, Shell - hard capsule, Tablet coatings, Thin films, Topical, Capsules, Other, Solutions, Suspensions, Tablets, Controlled release hydrophilic matrix, Hot melt extrusion, Muco-adhesive, Osmotic pump, Muco-adhesive, Rheology modifier, Rheology modifier/stabilizer, Thin films, Topical. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Document(s): certificate data msds. Avicel Microcrystalline Cellulose Physical Properties. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . P}MFbN#[>r(y << MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; Terms and Conditions Compliance Solutions Industries About 3E News & Events . Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? The most. : 9004-34-6 Date Approved: 01/31/2008 . In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. CAS #: 9004-34-6 It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). 5 0 obj A schematic illustration of the manufacturing process for Avicel Microcrystalline cellulose is shown below. INCI. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. q9;v80 However, it yields non-digestible fibre. Thus, Avicel contributes no or very few calories to the food system. 2 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>> Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& Watch Now. Safety Data Sheet (SDS) Viewer. 1 0 obj The 'Substance identity' section is calculated from substance identification information from all ECHA databases. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. : 51395-75-6 Date Approved: 01/31/2008 Revision No. Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp.