Trial Holds Promise for Weekly Insulin for Type 2
By Serena Gordon
HealthDay Reporter
TUESDAY, Sept. 22, 2020 (HealthDay News) — Type 2 diabetes can be tough to control without medication. But for some people, the thought of daily shots makes them delay or avoid starting insulin therapy.
Now, new research offers some hope for those insulin avoiders — a once-a-week insulin injection may someday replace daily shots.
A phase 2 trial compared the new weekly insulin, called icodec, to the commonly used insulin glargine (Lantus, Basaglar), and found the new insulin led to a similar reduction in blood sugar levels. The weekly insulin also had a similar safety profile to daily insulin glargine.
“This is the first once-a-week injectable insulin, and this study suggests it’s as effective as taking insulin daily. If it does well through scrutiny in phase 3 trials, it could make life easier for people with type 2 diabetes,” explained Dr. Robert Gabbay, chief science and medical officer for the American Diabetes Association.
“Getting people to start insulin is often a challenge, but if you only have to do it once a week, that may help,” he added.
Once people get over the hurdle of starting weekly injections, Gabbay said, they’ll likely “be more adherent, have better blood sugar control and then fewer complications.”
The study was funded by icodec’s manufacturer, Novo Nordisk in Denmark. HealthDay reached out to the study researchers for comment, but they were unavailable.
Insulin is a hormone that helps the body process sugars from foods. Insulin ushers sugar from the blood into the body’s cells, where it can be used for fuel.
People with type 2 diabetes usually don’t use insulin efficiently, and they may not make enough insulin to keep up with the body’s demands. That’s when people with type 2 diabetes often need to start taking insulin. (In people with type 1 diabetes, the immune system mistakenly attacks healthy insulin-producing cells, destroying most of them. People with type 1 diabetes have no choice but to take insulin by injection or via an insulin pump.)
The latest study included nearly 250 people with type 2 diabetes, aged 18 to 75. None had received long-term insulin therapy before the trial.
Continued
The participants’ diabetes was considered inadequately controlled, with A1Cs of 7% to 9.5%. A1C is a measure that estimates blood sugar levels over two months or so. A1C goals vary by individual, but often the goal is to be under 7%.
During the six-month trial, half of the participants were randomly assigned to take weekly injections of icodec. The remaining volunteers took insulin glargine daily.
By the end of the trial, people taking icodec saw a 1.33 percentage point drop in their A1C. The insulin glargine group dropped by 1.15 percentage points. Both groups had average A1Cs under 7% after starting insulin therapy.
One concern with any type of insulin therapy is low blood sugar (hypoglycemia). Taking insulin is a balancing act. Too little insulin and your blood sugar levels stay too high, which can eventually lead to complications if that happens regularly. Too much insulin can cause your blood sugar to drop to dangerous levels that can make you feel awful, and lead to unconsciousness and even death if left untreated.
The two types of insulin had similar levels of severe hypoglycemic events. Most of the adverse events in this trial were mild, however.
Dr. Akankasha Goyal, an endocrinologist at NYU Langone Health in New York City, said, “This is a very promising, innovative treatment. The insulin gradually releases over seven days. So far, the efficacy and safety are similar between icodec and insulin glargine.”
Goyal added, “Right now, insulin is a daily injection and we have a lot of resistance toward it. Icodec is more convenient and the once-a-week injection is a selling point.”
Both Gabbay and Goyal said they can envision multiple groups that could be helped by a weekly insulin. One group, Gabbay noted, is older teens and young adults who have unpredictable lifestyles and might miss taking a daily insulin around the same time every day.
Another is elderly patients — whether they live on their own, have visiting nurse services or live in a nursing home.
“Making insulin simpler for people facing physical or cognitive challenges who are cared for by another person is potentially a benefit of weekly insulin. The chance for an error is less if medication is given once a week rather than seven times,” Gabbay explained.
Continued
Goyal said family or friends often assist her elderly patients, which can be tough if they need daily insulin. She said weekly insulin could certainly help in that situation.
Novo Nordisk hopes to start its phase 3 trials of icodec later this year.
If all goes well in the phase 3 trials, Goyal and Gabbay both expect the drug will eventually be available to people with both type 1 and type 2 diabetes.
The report, by Dr. Julio Rosenstock of the Dallas Diabetes Research Center at Medical City in Dallas, and colleagues was published Sept. 22 in the New England Journal of Medicine.
Konsekvensene kan virke skremmende, men det finnes alternativer. Cialis er et som til a behandle erektil dysfunksjon og er tilgjengelig fra lege.Cialis
Thermostat is a cutting-edge device that brings a new level of comfort and energy,
E4
count your rainbows free mp3
is it rare to see 2 rainbows
life musik mp3
hour mp3 free
one hour bongo mix
life musik mp3
kejadian 1
kejadian 24 1-67
renungan kejadian 17
4 songs free
4 na 5 mirror mp3 download
life musik mp3
asap rocky mp3
what is 1 train by asap rocky about
life musik mp3
10 feet tall mp3
1017 freestyle mp3 download
life musik mp3
membedakanmelia biyang asli
cara membedakan propolis asli dan palsu
bagaimana cara membedakan propolis asli dan palsu
cara printer canon
canon ix6800 default password
canon ix6820 reset
cara setting ospf
cisco setting up ospf
mikrotik ospf configuration step by step
10 sippy gill mp3 free
tere bin dus mint sippy gill
life musik mp3
10 songs mashup free
bollywood mashup songs old and new
life musik mp3
chalet en bois
casablanca morocco homes
chalet en bois maroc prix
the resource for MP3 a treasure of that perfectly suits.
Best MP3
the resource for downloads uncover treasure music that perfectly your.
makam siti bali
aashiqui songs free download320kbps
mp3 songs free downloadzip
aashiqui 2 english subtitles watch online
aashiqui 2 full movie english
aashiqui 2 full movie subtitles
aashiqui (1990 mp3 songs 320kbps zip file)
aashiqui 1990 mp3 songs free download 320kbps zip file tamil
aashiqui 1990 mp3 download pagal
aashiqui free hindi
vinyl
aashiqui
driver aspire e1 10
download aspire e1 10
download driver aspire e1-410 windows 7 64 bit
download driver acer windows
download driver acer aspire e1-410 windows 8 64 bit
dlaptop aspire e1-410 windows 7
download 8 64 bit
Simmy Ngiyesabadownload
Simmydownload
Simmy — Ngiyesaba mp3 is a music with its originality and unique sound. This song is filled with deep that.
benjamin bow down anddownload
songs bow down andhim
benjamin dube glory in his presence songs download
download benjamin amandla
spirit of praise benjamin songs download
through all mp3 download
Teacher ArrestedGalesburg PD
Galesburgr ArrestedGalesburg Wall’s
Teacher PD announced Wall’s. The (Third Level Important Questions) 12. Galesburg arts coach
plan comparisons android phones
phone comparisons android home
New weather forecast in New Lexington, OH. New Lexington Hourly Forecast 48 Hour. Weather Today Weather Hourly 14 Day Forecast Yesterday/PastWeather (Averages) Currently:
worship life song
worship lyrics home
How To Get Dark Blade V2To get the Dark Blade V2 or Yoru in Blox Fruits, you need to get a quest from an NPC called Robotmega. To cast a miracle, you must use a Chime, Talisman, or Special Weapons that can cast Miracles.
soccernet live premier
gospel life church
live in the United States, and it is no surprise that apartment applications can be difficult to navigate. The mission of the Office of Safety and Youth Development is to help schools to create and maintain a safe, orderly and supportive school environment
neon neon personalized
neon wedding signs
nd via E*TRADE Mobile and Pro clients. E*TRADE API Document Accounts API Overview This API retrieves the current account balance and related details for a specified account. jgong8811 Level 2 February 27, 2022 9:28 PM Yes I am asking for importing 1099-B. E*TRADE API Document Market API Overview The Market APIs provide information about market events. According
a Fruit Conversion evolving
Optavia Fruit Conversion ChartWith
locations where credit cards are accepted. Welcome to Circle K Fuel.
Or for a simpler approximate conversion just multiply by 3.
You also convert (popular) units. 5300 Kilometers to Miles Conversion.
29327: The meter (symbol m) is the fundamental unit of
length in the International System of Units (SI). you
coupon baby furniture cyber
coupon baby furniture shipping
locations where credit cards are accepted. Welcome to Circle K Fuel.
Or for a simpler approximate conversion just multiply by 3.
You also convert (popular) units. 5300 Kilometers to Miles Conversion.
Conversion: The meter (symbol m) is the fundamental unit of
length in the International System of Units (SI). Using
245 nexen n su1 winter tires
215 nexen n 45r17 winter continental
locations where credit cards are accepted. Welcome to Circle K Fuel.
Or for a simpler approximate conversion just multiply by 3.
You also Length (popular) units. 5300 Kilometers to Miles Conversion.
Miles: The meter (symbol m) is the fundamental unit of
length in the International System of Units (SI). formula
michelin 205 goodyear 225
defender 55r16 assurance 225
locations where credit cards are accepted. Welcome to Circle K Fuel.
Or for a simpler approximate conversion just multiply by 3.
You also can (popular) units. 5300 Kilometers to Miles Conversion.
to: The meter (symbol m) is the fundamental unit of
length in the International System of Units (SI). above,
life online alarm clock night
second online alarm clock youtube
locations where credit cards are accepted. Welcome to Circle K Fuel.
Or for a simpler approximate conversion just multiply by 3.
You also can (popular) units. 5300 Kilometers to Miles Conversion.
29327: The meter (symbol m) is the fundamental unit of
length in the International System of Units (SI). you
do free mechanic
that free diagnostics
locations where credit cards are accepted. Welcome to Circle K Fuel.
Or for a simpler approximate conversion just multiply by 3.
You also Millimeters (popular) units. 5300 Kilometers to Miles Conversion.
Conversion: The meter (symbol m) is the fundamental unit of
length in the International System of Units (SI). will
cls yazisi bana masal
320 yazisi bana bir
locations where credit cards are accepted. Welcome to Circle K Fuel.
Or for a simpler approximate conversion just multiply by 3.
You also 5300 (popular) units. 5300 Kilometers to Miles Conversion.
Meters: The meter (symbol m) is the fundamental unit of
length in the International System of Units (SI). get:
Rates
Affordable
locations where credit cards are accepted. Welcome to Circle K Fuel.
Or for a simpler approximate conversion just multiply by 3.
You also can (popular) units. 5300 Kilometers to Miles Conversion.
5300: The meter (symbol m) is the fundamental unit of
length in the International System of Units (SI). conversion
amatycooleru download
kubuhlungu download
locations where credit cards are accepted. K.
Or for a simpler approximate conversion just multiply by 3.
You also convert (popular) units. 5300 Kilometers to Miles Conversion.
Meters: (symbol of
Units (SI). Using